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2 edition of Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits found in the catalog.

Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits

Charles Edward Mayo

Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits

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  • 13 Currently reading

Published .
Written in English

    Subjects:
  • Dyphylline.

  • Edition Notes

    Statementby Charles Edward Mayo.
    The Physical Object
    Pagination58 leaves, bound :
    Number of Pages58
    ID Numbers
    Open LibraryOL14231877M

      Nsubstituted derivatives of theophylline, such as dyphylline, have not been recommended for rapid intravenous administration. Conventional wisdom dictates that a methyl xanthine compound, such as aminophylline, should be infused slowly, i.e. over twenty minutes as a loading dose and then reduced at the end of twenty minutes.


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Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits by Charles Edward Mayo Download PDF EPUB FB2

Graduate Thesis Or Dissertation Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits Public Deposited. Analytics × Add to Author: Charles Edward Mayo. Theophylline pharmacokinetics following oral and intravenous administration were studied, and the absolute bioavailability of five commercially available products was determined using the rabbit as an in vivo by: The pharmacokinetics and bioavailability of 3 oral dyphylline preparations, solution (S), regular (R) and sustained release (SR), were studied in 8 healthy subjects (mean age 25 years).

A single dose of each preparation, 20 mgkg −1, was given at one week intervals and multiple serum samples obtained over 24 h. Drug levels were measured by high performance liquid by: 4. Graduation date: The bioavailability and pharmacokinetics of theophylline\ud in rabbits were determined following both oral and\ud intravenous administration of the drug.

Serum theophylline\ud concentrations were determined using high pressure\ud liquid chromatography. 1 Pharmacokinetics of theophylline were investigated in a group of healthy adult volunteers (non smokers and on xanthine-free diet) following single oral administration of, and mg doses as tablets (Theodel).

2 Absorption of theophylline was rapid and followed first-order by: Interaction of curcumin and theophylline 51 J Chin Med 12(1):EFFECT OF CURCUMIN ON THEOPHYLLINE PHARMACOKINETICS IN RABBITS Hui Ching1, Shang-Yuan Tsai2, Su-Lan Hsiu2, Ping-Ping Wu2 and Pei-Dawn Lee Chao2 1Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan.

Theophylline clearance can be decreased by a high carbohydrate-low protein diet, as well as the ingestion of other methylxanthines such as caffeine. In contrast, a low carbohydrate-high protein diet, especially charcoal broiled meat, may enhance theophylline clearance.

Theophylline clearance is markedly increased by tobacco or marihuana by: Abstract: This study was a randomized double‐blind evaluation of three doses of dyphylline, theophylline, and placebo for blocking exercise‐induced bronchospasm (EIB).

Twenty patients aged 12 to 17 years took one of the following on five separate days prior to an exercise challenge: 10,15, or 20 mg/kg dyphylline; 6 mg/kg anhydrous theophylline; or by: Update on the pharmacokinetics of theophylline Article Literature Review (PDF Available) in Chest 88(2 Suppl)SS September with Reads How we measure 'reads'.

Theophylline is well absorbed when taken orally as a rapid-release tablet or when administered as a liquid solution. Bioavailability and rate of absorption of controlled-release preparations are more variable and influenced by formulation and food intake. Theophylline distributes rapidly into fat-free tissues and body water.

The pharmacokinetics and bioavailability of 3 oral dyphylline preparations, solution (S), regular (R) and sustained release (SR), were studied in 8 healthy subjects (mean age 25 years). A single dose of each preparation, 20 mg X kg-1, was given at one week intervals and multiple serum samples obtained over 24 by: 4.

In vitro release of the drug was examined in simulated gastric fluid at 37°C from spheres having three different cross-linking densities. The bioavailability of theophylline released from the microspheres of different cross-linking densities was studied in rabbits following single oral by: Al-Mohizea et al.

[10] studied the effects of Acacia catechu on the pharmacokinetics of theophylline, a CYP1Aenzyme-specific substrate, in rabbits. In their study, black catechu was given to. BIOAVAILABILITY AND PHARMACOKINETICS OF DYPHYLLINE AND THEOPHYLLINE IN RABBITS PART I.

THEOPHYLLINE INTRODUCTION Theophylline (1,3-dimethylxanthine) is an alkaloid closely related to caffeine and theobromine. Its pharmaco-logical actions include mild diuresis, myocardial stimula-tion, smooth muscle relaxation and bronchodilation [1].

Objective—To evaluate the bioavailability and pharmacokinetic characteristics of 2 commercially available extended-release theophylline formulations in dogs. Design—Randomized 3-way crossover study. Animals—6 healthy adult dogs.

Procedure—A single dose of aminophylline (11 mgkg –1 [5 mglb –1], IV, equivalent to mg of theophylline/kg [ mglb –1]) or extended-release Cited by: Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs Dyphylline is an analogue of theophylline and the\ud latter is the most popular member of the methyixanthine\ud family in use for the treatment of asthma.

to liberate dyphylline\ud in a controlled manner after administration was evaluated\ud as a. The pharmacokinetics and bioavailability of theophylline in horses were investigated following both intravenous and intragastric administration of aminophyllinc solutions at doses, corresponding to 15 and 10 mg/kg theophylline base.

A rapid distributive phase with a half‐life of approximately 15‐30 min was followed by a slower elimination half‐life averaging 15‐17h. The apparent volume. LUFYLLIN (dyphylline), a xanthine derivative, is a bronchodilator available for oral administration as tablets containing mg and mg of dyphylline.

Other ingredients: magnesium stearate, microcrystalline cellulose. The relative bioavailability of theophylline (anhydrous) extended-release tablets given in the fasting state in comparison to an immediate-release product was 59%.

Peak serum theophylline levels occurred at ± (SD) hours, with a normalized (to mg) peak level being ± (SD). Dyphylline is a phosphodiesterase inhibitor used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis.

Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It also acts as an adenosine receptor antagonist. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP.

Dyphylline is an oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis.

It is also an ingredient in preparations that have been promoted for coughs. A steady-state crossover bioavailability study in 22 normal males compared two Uniphyl (theophylline anhydrous tablet) mg Tablets administered q24h at 8 a.m.

immediately after breakfast with a reference controlled-release theophylline product administered BID in fed subjects at 8 a.m. immediately after breakfast and 8 p.m. immediately after. The relative bioavailability of Theophylline (Anhydrous) Extended-Release Tablets given in the fasting state in comparison to an immediate-release product was 59%.

Peak serum theophylline levels occurred at ± (SD) hours, with a normalized (to mg) peak level being ± (SD). ng pk, locock ra; comparative pharmacokinetics of theophylline & dyphylline following iv injection in rabbits; res commun chem pathol pharmacol 26 (3): () Route of Elimination Dyphylline exerts its bronchodilatory effects directly and, unlike the ophylline, is excreted unchanged by the kidneys without being metabolized by the en Bond Acceptor Count: 5.

There are 4 disease interactions with Neothylline (dyphylline): Dyphylline is eliminated almost entirely by the kidney. Drug accumulation may occur in patients with impaired renal function. Like other methylxanthines, high plasma levels of the drug may be associated with severe cardio- and neurotoxicity, sometimes without any previous warning.

Pharmacokinetics of green tea catechins have been studied using defined green tea catechin extract (GTE), Polyphenon E, and EGCG with variable doses of administration [14, 15].

Oral bioavailability of tea catechins in human plasma was found having 5 to 50 times lower than the level needed to exert biological activities in in vitro systems [16, 17].Cited by: 2.

Uniphyl (theophylline) Disease Interactions. There are 7 disease interactions with Uniphyl (theophylline): Methylxanthines are known to stimulate peptic acid secretion. Therapy with products containing methylxanthines should be administered with extreme caution in patients with active peptic ulcer disease/ Thieme E-Books & E-Journals.

Abstract. Aim: The present study was conducted to investigate the effect of commonly used herb Commiphora myrrha on the pharmacokinetic profile of theophylline (narrow therapeutic index drug) in rabbits.

Methods: In the experimental groups, theophylline (16 mg/kg) was given orally to the rabbits. Where aqueous saline suspension of Commiphora myrrha ( mg/kg, p.o.

Pharmacokinetics Absorption. When theophylline is administered intravenously, bioavailability is %. Distribution. Theophylline is distributed in the extracellular fluid, in the placenta, in the mother's milk and in the central nervous system.

The volume of distribution is L/kg. The protein binding is 40%.Legal status: AU: S4 (Prescription only), CA: ℞-only. List of Approved Drug Products containing Theophylline in the FDA Orange Book on   Objective—To evaluate the pharmacokinetics of a brand of extended-release theophylline tablets and capsules in healthy cats.

Design—Randomized 3-way crossover study. Animals—6 healthy cats. Procedures—A single dose of aminophylline (10 mg/kg [ mg/lb], IV), a mg extended-release theophylline tablet, or a mg extended-release theophylline capsule was Cited by: 2.

Piperine with Propranolol and Theophylline The effects of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline were studied. Six subjects in each group received a single oral dose of propranolol (40 mg) or theophylline ( mg) alone or in combination with piperine (20 mg) daily for 7 by: Slo‐bid® was predicted to provide the least peak: trough fluctuation in theophylline concentrations.

Slo‐bid® and Theo‐Dur® appear to have pharmacokinetic characteristics which, if given once‐daily, would maintain plasma theophylline concentrations of 5–20 μg/ml in the by: The effects of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline were studied.

Six subjects in each group received a single oral dose of propranolol (40 mg) or theophylline ( mg) alone or in combination with piperine (20 mg) daily for 7 days.

Dyphylline: (Major) Dyphylline is a xanthine derivative and should not be administered with other methylxanthines (e.g., theophylline, aminophylline, and others) due to the duplicative nature of therapy and the potential increased risk for methylxanthine-related side effects such as nausea, irritability, or nervousness.

Adverse effects such as. Javascript Is Disabled. PharmGKB requires. The pharmacokinetics of theophylline were investigated in dogs following intravenous, single oral, and multiple oral doses of aminophylline.

Mean half-life (t1/2) of theophylline following single intravenous administration was h and the apparent specific volume of distribution (V'd area) was litre/ by: Describe the differences between linear pharmacokinetics and nonlinear pharmacokinetics. Illustrate nonlinear pharmaco­kinetics with drug disposition examples.

Discuss some potential risks in dosing drugs that follow nonlinear kinetics. Explain how to detect nonlinear kinetics using AUC-versus-doses plots.

Effect of multiple-dose tacrine administration on single-dose pharmacokinetics of digoxin, diazepam, and theophylline. Pharm Res ;10(10):S Full Drug Information. Theophylline/Food Interaction Interactions.

Food does not effect in bioavailability of theophylline from Theolin Retard. Eur J Clin Pharmacol ;26(3) M, Jonkman JH. Greatly. Bioavailability of Two Sustained-release Theophylline Products in Healthy Males The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U.S. Federal Government.Theophylline is readily absorbed in the ruminating calf after oral administration with a mean bioavailability (F) of The plasma concentrations following oral dosing peak in approximately hours with a mean absorption half-life of hours.

The drug is extensively absorbed across the rumen epithelium (mean 81%).Ceftibuten: (Minor) H2-blockers can affect the pharmacokinetics of some orally-administered cephalosporins. The oral bioavailability of ceftibuten was reported to be increased by the administration of mg of ranitidine PO every 12 hours for 3 days, but this interaction is of unknown clinical relevance.